Sunday, April 25, 2021

History of dopamine

Dopamine is a neurotransmitter, synthesized in both central nervous system and the periphery. Dopaminergic system plays important roles in neuromodulation, such as motor control, motivation, reward, cognitive function, maternal, and reproductive behaviors.

This neurotransmitter is involved in the control of movement and Parkinson’s disease, the neurobiology and symptoms of schizophrenia and attention deficit hyperactivity disorder.

Synthesized in 1910 by Barger and Ewins (1910) and by Mannich and Jacobsohn (1910), dopamine (3-hydroxytyramine, B-3,4-dihydroxyphenylethylamine) was classified - in the same year - by Barger and Dale (1910) as a weak sympathomimetic (vasopressor) drug. And it was Henry Dale who first suggested the shorter name dopamine in 1952.

In 1942, Holtz reported a novel observation that administration of low dose dopamine to the guinea pig resulted in lowering of arterial pressure.

Herman Blaschko at Oxford, who worked on monoamine oxidase (MAO) in the early years was one of the first to suggest that dopamine may be physiologically significant, a view substantiated by studies showing that dopamine could lower blood pressure and this effect was potentiated by inhibition of MAO.
History of dopamine
at 9:14 AM
Labels: ,

The most popular articles

  • History of Paracetamol
    Paracetamol is a very widely used as medicine. It is painkiller and reduces the temperature of patients with fever. These actions are know...
  • Discovery of oxygen
    Arising from the earlier entities of phlogiston and combustible air, oxygen was the product of several interconnected and near simultaneousl...
  • Discovery of quinine
    The discovery of quinine marked the beginning of modern pharmacology. The first recorded account use of quinine came at the Viceregal Pla...
  • Discovery of Staphylococcus aureus
    Alexander Ogston (1844-1929) was a Scottish surgeon who in 1880 first observed staphylococci while performing experiments to prove his theor...
  • Discovery of morphine by Friedrich Sertürner
    The use of a wide of variety of opium alkaloids, obtained from the dried sap of Papaver somniferum , has been reported ins several cultures...
  • History of ADHD (attention deficit hyperactivity disorder)
    The earliest literature referring to the inattentive subtype of ADHD dates back to the writings of the physician, Alexender Crichton in 1798...
  • History of Metabolic syndrome
    The “metabolic syndrome” is a clustering of components that reflect overnutrition, sedentary lifestyles, and resultant excess adiposity. Met...
  • Galen on Herophilus
    Galen on Herophilus Herophilus ‘attained the highest degree of accuracy in things which became known by dissection and he obtained the grea...